Meta-analysis of the efficacy of oral antibiotics treatment with parenteral antibiotics treatment in commu-nity acquired pneumonia children
10.3760/cma.j.issn.1673-4408.2017.09.011
- VernacularTitle:儿童社区获得性肺炎口服与非口服抗生素疗效比较的Meta分析
- Author:
Juan XU
1
;
Yong YIN
;
Lixia ZHAO
;
Fengjuan JI
;
Yajuan ZHOU
;
Lei ZHU
Author Information
1. 200127,上海交通大学医学院附属上海儿童医学中心呼吸科
- Keywords:
Community acquired pneumonia;
Children;
Oral;
Parenteral;
Meta-analysis
- From:
International Journal of Pediatrics
2017;44(9):626-632
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the efficacy of oral treatment and parenteral treatment in community acquired pneumonia( CAP) children by meta-analysis method. Methods Searches were made in MEDLINE、EMBASE and Cochrane Central Register of Controlled Trials ( CENTRAL ) from the establishment of the data base till September 2016. All randomized controlled trials about oral and parenteral treatment in community ac-quired pneumonia children were eligible. Review Manager 5. 3 was used to analyze the studies enroued in this meta-analysis. Results 4582 literatures were reviewed. Seven(n=5030)eligible trials were used for meta-a-nalysis. The treatment failure between community acquired pneumonia children treated with oral treatment and parenteral treatment was found no significant difference(OR =0. 82, 95% CI =0. 63-1. 08,P <0. 05). The treatment failure of oral treatment group was found to be significantly higher than parenteral treatment group in CAP children under 1 year of age(OR=2. 25,95%CI=1. 61-3. 14,P<0. 01). The treatment failure of children who had used antibiotics before included in the study was found to be significantly higher than those who had not used(OR=1. 94,95%CI=1. 50-2. 50,P<0. 01). The death rate of oral treatment group was found to be signif-icantly lower than the parenteral treatment group(OR=0. 31,95%CI=0. 11-0. 85,P=0. 02). There was no sig-nificant difference of relapse rate (OR=1. 28,95%CI=0. 34-4. 82) and loss to follow-up rate(OR=1. 08,95%CI=0. 77-1. 51) between the two group. Conclusion Oral treatment is as effective as parenteral treatment in CAP children. The death rate of oral treatment group is significantly lower than the parenteral treatment group.
