Correlations of Dynamic Contrast-Enhanced Magnetic Resonance Imaging with Morphologic, Angiogenic, and Molecular Prognostic Factors in Rectal Cancer.
10.3349/ymj.2013.54.1.123
- Author:
Hye Suk HONG
1
;
Se Hoon KIM
;
Hae Jeong PARK
;
Mi Suk PARK
;
Ki Whang KIM
;
Won Ho KIM
;
Nam Kyu KIM
;
Jae Mun LEE
;
Hyeon Je CHO
Author Information
1. Department of Medicine, Graduate School, Yonsei University, Seoul, Korea.
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Colorectal neoplasms;
prognosis;
diagnostic imaging;
magnetic resonance imaging
- MeSH:
Adult;
Aged;
Aged, 80 and over;
Cell Differentiation;
Contrast Media/*pharmacology;
DNA Mutational Analysis;
Female;
Gadolinium/pharmacology;
Genes, ras;
Humans;
Magnetic Resonance Imaging/*methods;
Male;
Microcirculation;
Microsatellite Instability;
Middle Aged;
Neoplasm Staging;
Neovascularization, Pathologic;
Prognosis;
Rectal Neoplasms/*diagnosis/genetics/*pathology;
Retrospective Studies;
Time Factors
- From:Yonsei Medical Journal
2013;54(1):123-130
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: To investigate the correlations between parameters of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and prognostic factors in rectal cancer. MATERIALS AND METHODS: We studied 29 patients with rectal cancer who underwent gadolinium contrast-enhanced, T1-weighted DCE-MRI with a three Tesla scanner prior to surgery. Signal intensity on DCE-MRI was independently measured by two observers to examine reproducibility. A time-signal intensity curve was generated, from which four semiquantitative parameters were calculated: steepest slope (SLP), time to peak (Tp), relative enhancement during a rapid rise (Erise), and maximal enhancement (Emax). Morphologic prognostic factors including T stage, N stage, and histologic grade were identified. Tumor angiogenesis was evaluated in terms of microvessel count (MVC) and microvessel area (MVA) by morphometric study. As molecular factors, the mutation status of the K-ras oncogene and microsatellite instability were assessed. DCE-MRI parameters were correlated with each prognostic factor using bivariate correlation analysis. A p-value of <0.05 was considered significant. RESULTS: Erise was significantly correlated with N stage (r=-0.387 and -0.393, respectively, for two independent data), and Tp was significantly correlated with histologic grade (r=0.466 and 0.489, respectively). MVA was significantly correlated with SLP (r=-0.532 and -0.535, respectively) and Erise (r=-0.511 and -0.446, respectively). MVC was significantly correlated with Emax (r=-0.435 and -0.386, respectively). No significant correlations were found between DCE-MRI parameters and T stage, K-ras mutation, or microsatellite instability. CONCLUSION: DCE-MRI may provide useful prognostic information in terms of histologic differentiation and angiogenesis in rectal cancer.
