Expression of Wntless in gastric carcinoma and its clinical significance
- VernacularTitle:Wntless在胃腺癌组织中表达及其意义
- Author:
hao Chang CHEN
1
;
jun Yue SUN
;
ming Hong XU
;
ping Jian ZHANG
Author Information
1. 南京医科大学第二附属医院 普外科
- Keywords:
Wnt;
Wntless;
gastric carcinoma;
IHC
- From:
Basic & Clinical Medicine
2017;37(10):1440-1443
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the expression of Wnt secret protein Wntless in gastric carcinoma and normal mu-cosa,and to analyze the clinical significance of Wntless expression. Methods To detecte the expression of Wntless protein in gastric adenocarcinoma and normal gastric mucosa by immunohistochemistry. Results In 104 specimens of gastric cancer,the expression of Wntless in gastric adenocarcinoma was: 7.7% (8/104) cases were 0 or 1+, 36.5% (38/104) cases were 2+,and 55.8% (58/104) cases were 3+. While in normal mucosa,the expression of Wntless was:71.2% (74/104) cases were 0 or 1+, 19.2% (20/104) cases were 2+, and 9.6% (10/104) cases were 3+.The expression of Wntless in gastric adenocarcinoma was significantly higher than that in normal gas-tric mucosa (P<0.001). The expression of Wntless protein was positively correlated with tumor differentiation(P<0.05),and was positively correlated with lymph node metastasis (P<0.05).Conclusions Wntless is highly ex-pressed in gastric carcinomas and may have role in the oncogenesis. Wntless may be used as a new marker for pro-gression and metastasis of gastric carcinoma.
