Research progress on epidemiology and pathogenesis of neoplasms in acromegaly
- VernacularTitle:肢端肥大症合并肿瘤的流行病学及发病机制研究进展
- Author:
Wei LIN
1
;
peng Xiao GUO
;
Bing XING
Author Information
1. 中国医学科学院 北京协和医学院 北京协和医院 神经外科
- Keywords:
acromegaly;
neoplasm;
epidemiology;
pathogenesis;
insulin-like growth factor 1
- From:
Basic & Clinical Medicine
2017;37(10):1474-1477
- CountryChina
- Language:Chinese
-
Abstract:
Neoplasms are well known to be a complication in cases of acromegaly,especially thyroid and colorectal neoplasia. The incidence and mortality of neoplastic complications in acromegaly patients are higher than that of the general population,the pathogenesis of which is correlated with elevated serum levels of insulin-like growth factor 1 (IGF-1) and activation of IGF-1 signaling pathway. Early screening and intervention of neoplastic complications play an important role in decreasing the mortality of acromegaly patients.
