Advance in the study of pyroptosis in renal inflammatory injury
- VernacularTitle:细胞焦亡在肾脏炎性损伤中的作用研究进展
- Author:
sheng Yan WU
1
;
dong Jian GAO
Author Information
1. 上海中医药大学附属曙光医院 肾病科 上海中医药大学中医肾病研究所 上海市中医临床重点实验室
- Keywords:
kidney inflammation;
pyroptosis;
NLRP3;
caspase-1;
GSDMD
- From:
Basic & Clinical Medicine
2017;37(10):1470-1473
- CountryChina
- Language:Chinese
-
Abstract:
Pyroptosis is activated caspase-1 trigger special programmed cell. Recent studies have confirmed the py-roptosis in renal cells plays an important role. GSDMD cleavage caspase-1 regulating the downstream inflammatory cytokines maturation、release and triggering inflammation and pyroptosis. From renal inflammatory injury caused by NLRP3 activation, pyroptosis from GSDMD breakage, the review try to explain the NLRP3-caspase-1-GSDMD drived pyroptosis in renal inflammation injury to explore the essence of kidney inflammatory damage.
