Application progresses of Gadolinium-based nanomaterials contrast media in MRI
10.13929/j.1003-3289.201703073
- VernacularTitle:基于钆的纳米对比剂MRI应用进展
- Author:
Wenwen CAI
1
;
Lingjie WANG
;
Huajie YUE
;
Ruiping ZHANG
Author Information
1. 山西医科大学第一医院影像科
- Keywords:
Magnetic resonance imaging;
Gadolinium;
Contrast media;
Nanomaterials;
Relaxation
- From:Chinese Journal of Medical Imaging Technology
2017;33(10):1475-1478
- CountryChina
- Language:Chinese
-
Abstract:
Recently clinical MR contrast media consists mainly of gadolinium based small molecule complexes,such as Gd-dTPA,Gd dOTA,etc,but small molecule complexes are defective in the relaxation and early diagnosis.With the development of nanotechnology,molecular nanoprobes not only have the advantages of small particle size,good biocompatibility,enhanced penetration and retention (EPR) effect and long half-life,but also their relaxation rates are higher than that of common gadolinium contrast media.The application of current MR molecular probe,such as liposomes,dendrimers,mesoporous silica,polymer micelles,carbon nanotubes,nano-gold and paramagnetic nanoparticles were mainly introduced in this paper.
