Study on the Extraction Technology of Compound Radix Fici Hirta Granule

VernacularTitle:复方五指毛桃颗粒的提取工艺研究
Author: Lina SUN ¹ ; Xiaohong LIU ; Jianbo LIU ; Yaoxin SHAO ; Huiting HUANG ; Zhiqiang ZHANG ; Shuohui WANG ; Zhenhua WANG
Author Information

1. 广州中医药大学中药学院,广州510006
Keywords: Compound radix fici hirta granule; Uniform design; Extraction technology; Psoralen; Amygdalin
From: China Pharmacy 2017;28(28):3976-3979
CountryChina
Language:Chinese
Abstract: OBJECTIVE:To optimize the extraction technology of Compound radix fici hirta granule. METHODS:Using the transfer rate of psoralen and amygdalin in extraction liquid of Compound radix fici hirta granule and extraction rate as indexes, U12(6×4×3)uniform design was used for the test,the effects of amount of adding water,extraction time,extraction times on the extraction technology were investigated,and optimized technology was verified by three pilot scale tests. RESULTS:The optimal technology was as follow as 10-fold water,extracting for 3 times,60 min each time. Under the conditions,transfer rate of pso-ralen and amygdalin and extraction rate were 82.51%(RSD=1.45%,n=3),93.69%(RSD=0.85%,n=3),18.89%(RSD=0.74%,n=3),respectively. The validated results were in the 95% confidence interval of predictive value. CONCLUSIONS:The optimized extraction technology is stable and feasible,and provides the scientific basis for the follow-up development of the prepa-ration.