Expression of ER,HNF-1β and COX-2 in endometriosis-associated ovarian cancer and its clinical significance
10.3969/j.issn.1671-8348.2017.27.018
- VernacularTitle:ER、HNF-1β及COX-2在子宫内膜异位相关性卵巢癌中的表达及临床意义
- Author:
Ying CHEN
1
;
Qifang LONG
Author Information
1. 苏州大学附属第二医院妇产科 215004
- Keywords:
ovarian neoplasms;
estrogen receptor;
hepatocyte nuclear factor 1β;
cyclooxygenase
- From:
Chongqing Medicine
2017;46(27):3801-3803,3807
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression difference of estrogen receptor(ER),hepatocyte nuclear factor 1β(HNF-1β) and epoxy-2(COX-2) in different types of endometriosis-associated ovarian cancer (EAOC).Methods Forty-four patients with EAOC treated in our hospital from July 2011 to April 2016 were selected,including 17 cases of endometrioid carcinoma,21 cases of clear cell carcinoma and 6 cases of ovarian serous carcinoma.The expression of ER,HNF-1β and COX-2 in different types of EAOC were detected by immunohistochemistry.The correlation among expression levels of ER,HNF-1β and COX-2 was investigated by adopting Spearman rank correlation analysis.Results The positive rate of ER in endometrioid carcinoma was 100.0％,which was significantly higher than 9.5％ in the patients with clear cell carcinoma and 0％ in the patients with ovarian serous carcinoma(x2=4.305,P＜0.01),and the positive rate of HNF-1β in the patients with clear cell carcinoma and ovarian serous carcinoma were 85.7％ and 100.0％ respectively,which was significantly higher than 11.8％ in the patients with endometrioid carcinoma(x2 =3.585,P＜0.01),the positive rates of COX-2 in the patients with endometrioid carcinoma,clear cell carcinoma and ovarian serous carcinoma were 76.5％,81.0％ and 83.3％,respectively,and the difference was not statistically significant (x2 =0.744,P =0.104).The correlation analysis showed that ER was negatively correlated with HNF-1β expression level(r=-0.428,P＜0.01)and positively correlated with COX-2 expression level (r=0.204,P=0.013).Conclusion ER is mainly expressed in endometrioid carcinoma.HNF-1β is mainly expressed in clear cell carcinoma and ovarian serous carcinoma.The expression level of ER had a certain correlation to the expression of HNF-1β and COX-2,which may be closely related to EAOC progression.
