Study on correlation between levels of hs-CRP, IL-6 and MMP-9 with cerebral microbleeding
10.3969/j.issn.1671-8348.2017.26.010
- VernacularTitle:炎症介质hs-CRP、IL-6和MMP-9水平与脑微出血的相关性研究
- Author:
Qiaoli LU
1
;
Chen LI
;
Zhirong JIA
Author Information
1. 天津市第五中心医院神经内科
- Keywords:
cerebral hemorrhage;
C-reactive protein;
interleukin-6;
matrix metalloproteinase 9;
cerebral microbleeding;
risk factor;
inflammatory mediator
- From:
Chongqing Medicine
2017;46(26):3629-3631
- CountryChina
- Language:Chinese
-
Abstract:
Objective To discuss the correlation between levels of hs-CRP,IL-6 and MMP-9 with cerebral microbleeding (CMB).Methods A total of 201 of non-acute ischemic cerebrovascular were collected and performed heal MRI+ susceptibility-weighted imaging(SWI).The patients were divided into the CMB group(49 cases) and non-CMB group(152 cases) according to the SWI examination results.The clinical data were recorded in the two groups.The levels of inflammatory mediators high-sensitivity C-reactive protein (hs-CRP),interleukin-6 (IL-6) and matrix metalloproteinase-9(MMP-9) were tested.The Logistic regression analysis was used to analyze the relation between the levels of hs-CRP,IL-6 and MMP-9 with cerebral microbleeding.Results The levels of inflammatory mediators hs-CRP,IL-6 and MMP-9 in the CMB group were significantly higher than those in the non-CMB group (P＜0.05).The logisticMultivariate logistic regression analysis showed that the levels of hs-CRP,IL-6 and MMP-9[OR value(95％CI):1.745(1.342-2.270),1.223(1.018-1.533),1.284(1.082-1.423),P＜0.05)] were the risk factors of CMB after adjusting the influence of age,sex and traditional risk factors.Conclusion The levels of inflammatory mediators hs-CRP,IL-6 and MMP-9 are closely associated with CMB,which participate in CMB occurrence.
