Improvement Effects of Citalopram Combined with Huperzine A in Aged Depression Model Rats
10.6039/j.issn.1001-0408.2017.28.10
- VernacularTitle:西酞普兰联合石杉碱甲对老年抑郁模型大鼠的改善作用
- Author:
Panpan TAN
1
;
Meng LIU
;
Xiuying LI
;
Pengyan ZHANG
;
Yuchen DU
Author Information
1. 濮阳市卫生学校教务处基础教研室
- Keywords:
Citalopram;
Huperzine A;
Combined treatment;
Aged rats;
Depression;
Learning and memory
- From:
China Pharmacy
2017;28(28):3923-3926
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the improvement effects of citalopram combined with huperzine A in aged depression model rats. METHODS:Aged rats were randomly divided into blank control group,model group,huperzine A group(0.3 mg/kg),citalo-pram group(5 mg/kg),and combination group(huperzine A 0.3 mg/kg+citalopram 5 mg/kg),10 in each group. Except for blank control group,rats in other groups received chronic unpredictable mild stress to reduce depression model. After modeling,rats were intragastrically administrated relevant drugs once a day,for 2 weeks. The depression,learning and memory behavior changes of rats in each group were observed by using open-field test,sucrose consumption test,tail suspension test,forced swimming test and Morris water maze test. RESULTS:Compared with blank control group,the horizontal crossing number,uprightness number,su-crose preference rate,crossing number in platform,percentages of target quadrant distance and time of rats in model group were ob-viously decreased (P<0.05 or P<0.01);immobility time of tail suspension and swimming,escape latency were obviously pro-longed(P<0.05 or P<0.01). Compared with model group,the depression-related indexes of rats in citalopram group and combina-tion group were obviously improved(P<0.05 or P<0.01),and combination group had better effects;the learning and memory-re-lated indexes in combination group were obviously improved(P<0.05 or P<0.01),only crossing time in platform in huperzine A group and citalopram group were obviously increased (P<0.05 or P<0.01),and other learning and memory-related indexes had no obvious changes(P>0.05). CONCLUSIONS:Citalopram combined with huperzine A can obviously improve the depression be-havior,learning and memory ability of aged rats with depression,showing better effects than citalopram alone.
