Association between endothelial injury and organ dysfunction in sepsis
10.3760/cma.j.issn.2095-428X.2017.18.020
- VernacularTitle:脓毒症内皮系统损伤与器官功能障碍的关联
- Author:
Tiannan ZHANG
1
;
Qiyi ZENG
Author Information
1. 南方医科大学珠江医院儿科中心
- Keywords:
Sepsis;
Endothelium;
Glycocalyx;
Organ dysfunction
- From:
Chinese Journal of Applied Clinical Pediatrics
2017;32(18):1438-1440
- CountryChina
- Language:Chinese
-
Abstract:
The definition of sepsis has been updated as life-threatening organ dysfunction caused by a dysregulated host response to infection according to the Third International Consensus Definitions for Sepsis and Septic Shock (SEPSIS-3).Sepsis affects functions of endothelial cell (EC) which include vasoregulation,barrier function,inflammation,hemostasis,and is thought to be the key factor in the progression from sepsis to organ failure.Recent studies also demonstrated the mechanism of endothelial dysfunction in sepsis is mediated by glycocalyx shedding.This review covers the current insight in sepsis-associated endothelial dysfunction in different organ systems,as well as the clinical assessmeut and clinical trial aiming at the system of endothelium.
