Establishment and Application of Content Determination Method for 7 Elements in Gelatin Hollow Capsule
10.6039/j.issn.1001-0408.2017.28.28
- VernacularTitle:明胶空心胶囊中7种元素含量测定方法的建立与应用
- Author:
Faying WANG
1
;
Chaqing WU
Author Information
1. 丽水市食品药品与质量技术检验检测院
- Keywords:
Gelatin hollow capsule;
Element;
Atomic fluorescence spectrometry;
Graphite furnace atomic absorption spectrom-etry;
Flame atomic absorption spectrometry;
Commercially available samples
- From:
China Pharmacy
2017;28(28):3992-3995
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To provide reference for improving the quality of Gelatin hollow capsule. METHODS:Atomic fluo-rescence spectrometry was used to determine the contents of Hg,As in Gelatin hollow capsule;graphite furnace atomic absorption spectrometry was used to determine the contents of Cr,Pb,Cd;flame atomic absorption spectrometry was used to determine the contents of Cu,Zn;and the contents of 7 elements in 48 batches of commercially available Gelatin hollow capsule were deter-mined. RESULTS:Each element showed good linear relationship in each mass concentration range(Cr,Pb,Cd,As and Hg were respectively 0-10,0-20,0-1.5,0-10,0-1.0μg/L;Cu and Zn were 0-1.8 mg/L)(r≥0.9969). The detection limits of Cr,Pb,Cd, Cu,Zn,Hg and As were 0.065,0.007,0.011,0.004,0.010,0.108,0.004 μg/L,respectively. RSDs of precision tests were no more than 2.5%(n=6);RSDs of reproducibility tests were no more than 7.5%(n=6);average recoveries ranged in 88.6%-109.5%(RSD≤6.7%,n=6). The contents of 7 elements in the 48 batches of samples were in line with the relevant provi-sions in Chinese Pharmacopoeia(2015 edition,part 4)and pharmacopoeia or standards in other countries or organizations. CON-CLUSIONS:The method shows high sensitivity,high precision with accurate and reliable results,and can be used for the content determination of Cr,Pb,Cd,Cu,Zn,Hg and As in Gelatin hollow capsule. The 48 batches of Gelatin hollow capsule from differ-ent manufacturers have good quality.
