Observation on effect of β-blocker in treating dilated cardiomyopathy in children
10.3969/j.issn.1671-8348.2017.26.019
- VernacularTitle:β受体阻滞剂治疗小儿扩张型心肌病的疗效观察
- Author:
Qing MEN
1
;
Enyi WEN
Author Information
1. 第三军医大学新桥医院儿科
- Keywords:
cardiomyopathy,dilated;
adrenergic beta-antagonists;
endothelins;
drug therapy;
ventricular function;
child;
hypertension
- From:
Chongqing Medicine
2017;46(26):3655-3657
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of β-blocker on dilated cardiomyopathy (DCM) in children.Methods Sixty-one children cases of DCM in this hospital from 1995 to 2015 were retrospectively analyzed and divided into the treatment group(taking β-blocker,n=35) and control group(non-taking β-blocker,n=26) according to whether taking β-blocker.The clinical effect of β-blocker was preliminarily observed.Results The heart rate,LVDD,LVSD and LA after treatment in the treatment group were significantly decreased compared with before treatment(P＜0.05),while EF was significantly increased(P＜0.05);LVDD after treatment in the control group was significantly decreased(P＜0.05),while hear rate,RV,LVDD,LVSD,LA,MV and EF had no obvious change compared with before admission(P＞0.05).The heart rate,LVDD,LVSD and EF after treatment had statistical difference between the treatment group and control group (P＜0.05),the heart function after treatment in the treatment group was significantly improved compared with the control group (P＜0.05).The heart function improvement degree after treatment in the patients with hypertension of the treatment group was significantly better than those with normal blood pressure(P＜0.05).DCM with hypertension was significantly improved after treatment and was better than DCM without hypertension (P＜0.05).The The heart function improvement degree after treatment in the patients with carvedilol treatment was obviously better than that in the patients with metoprolol treatment(P＜0.05).Conclusion β-blocker could be used in the treatment of DCM,its effect is especially good in DCM children patients with hypertension,in which the effect of carvedilol is better than that of metoprolol.
