Prognostic evaluation of high sensitivity-C reactive protein in peripheral T-cell lymphoma
10.3969/j.issn.1000-8179.2017.17.553
- VernacularTitle:超敏C反应蛋白水平对外周T细胞淋巴瘤患者预后意义的临床研究
- Author:
CHEN YELONG
1
;
XIE WANZHUO
;
MA SHANSHAN
;
LU DANLEI
;
LI LI
;
ZHU JINGJING
;
YANG XIUDI
;
ZHU LIXIA
;
ZHENG YANLONG
;
YE ZHOU
;
Xiujin DE
Author Information
1. 浙江大学医学院附属第一医院血液科 杭州市310003
- Keywords:
lymphoma;
T-cell;
peripheral;
high sensitivity-C reactive protein;
prognostic evaluation
- From:
Chinese Journal of Clinical Oncology
2017;44(17):851-856
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the prognostic significance of high sensitivity-C reactive protein (Hs-CRP) in patients with peripher-al T-cell lymphoma (PTCL). Methods:A total of 234 newly diagnosed PTCL patients with a median age of 48 years were analyzed retro-spectively. Serum Hs-CRP levels and other factors, including tumor stage and international prognostic index (IPI), were determined. Af-ter a median follow-up of 23 months, the relationship between Hs-CRP and overall survival (OS) was observed. Results:Serum Hs-CRP level positively correlated with IPI score (r=0.132, P<0.001), tumor stage (r=0.183, P=0.005), B symptoms (r=0.225, P=0.001), and lactic dehydrogenase (r=0.169, P=0.009), but negatively correlated with plasma albumin levels (r=?0.343, P<0.001), hemoglobin concentra-tion (r=?0.239, P<0.001), and platelet count (r=0.131, P=0.045), and is uncorrelated with age (P>0.05), gender (P>0.05), fitness score (P>0.05), and leukocyte count (P>0.05). Patients with serum Hs-CRP levels≤10 mg/L had better OS than patients with serum Hs-CRP levels>10 mg/L. Univariate and multivariate Cox regression models showed that platelet count, Hs-CRP, albumin levels, and IPI score were independent adverse prognostic factors. Conclusion:The baseline Hs-CRP level can serve as a major indicator of prognosis in PT-CL patients.
