The distribution of LAP+CD4+ T cells in gastric carcinoma microenvironment and its clinical significance
10.3760/cma.j.issn.1673-4904.2017.10.012
- VernacularTitle:LAP+CD4+T细胞在胃癌肿瘤微环境中的分布情况及临床意义
- Author:
Lanlan GUO
1
;
Guicheng WU
;
Kaiyuan LIU
;
Jianjun ZHENG
Author Information
1. 解放军第九五医院消化内科
- Keywords:
LAP+CD4+T cell;
Gastric cancer;
Tumor microenvironment
- From:
Chinese Journal of Postgraduates of Medicine
2017;40(10):912-915
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the distribution of LAP+CD4+T cells in gastric carcinoma microenvironment and the correlation of LAP + CD4 + T cells with the progression of gastric tumor. Methods Forty gastric tumor patients and 20 healthy donors were enrolled in this study. The percentage of LAP+CD4+T cells in the peripheral blood and tumor tissue was detected by flow cytometry. The correlation of LAP+CD4+T cells with the progression of gastric tumor was analyzed. Results The percentage of LAP+CD4+T cells in the peripheral blood of gastric tumor patients was higher than that of health donors:(10.9±3.3)%vs. (4.3 ± 1.2)%;the percentage of LAP+CD4+T cells from tumor tissue was higher than that from non-tumor tissue:(13.5 ± 5.3)%vs. (4.7 ± 1.4)%. The percentage of LAP+CD4+T cells in peripheral blood from metastasis patients was higher than that from non-metastasis patients and health donors: (10.1 ± 6.4)% vs. (4.5 ± 1.3)% and (4.3 ± 1.2)%. Conclusions LAP+ CD4+ T cells accumulates in gastric carcinoma microenvironment and the percentage of LAP+CD4+T cells increases along with the progression of gastric tumor.
