The antidepressant effect of subanesthestic dose ketamine in anesthesia after cesarean section
10.3760/cma.j.issn.1673-4904.2017.10.014
- VernacularTitle:术中使用亚麻醉剂量氯胺酮对剖宫产术后抗抑郁作用观察
- Author:
Jinsong ZHOU
1
;
Jianhui RUAN
;
Guosheng GAN
;
Rong ZHANG
;
Lin LI
;
Mingchun WU
Author Information
1. 解放军武汉总医院麻醉科
- Keywords:
Anesthesia;
Ketamine;
Cesarean section;
Depression;
Retrospective studies
- From:
Chinese Journal of Postgraduates of Medicine
2017;40(10):920-923
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the antidepressant effect of subanesthestic dose ketamine in anesthesia after cesarean section. Methods One hundred and twenty-six parturients who had underwent cesarean section were divided into ketamine group and control group with 63 cases each, The parturients in control group were given intravenous 0.9%sodium chloride 20 ml after childbirth, and the parturients in ketamine group were given subanesthetic dose ketamine after childbirth (0.5 mg/kg + 20 ml 0.9%sodium chloride). The parturients were evaluated by hospital anxiety and depression scale (HADS) and postpartum depression screening scale (PDSS). Results The scores of HADS and PDSS 5 and 10 d after parturition in ketamine group were significantly lower than those in control group, HADS:(7.67 ± 2.53) scores vs. (10.48 ± 2.48) scores and (7.96 ± 2.61) scores vs. (11.24 ± 2.74) scores, PDSS:(52.58 ± 13.36) scores vs. (71.34 ± 15.19) scores and (53.73 ± 13.28) scores vs. (73.41 ± 15.37) scores, and there were statistical differences (P<0.01). The incidences of depression 5 and 10 d after parturition in ketamine group were significantly lower than those in control group:4.8%(3/63) vs. 15.9%(10/63) and 4.8%(3/63) vs. 17.5% (11/63), and there were statistical differences (P<0.05). There were no serious adverse reactions in the 2 groups. Only 2 cases had mild nausea in control group, and the symptoms disappeared after adjustment. Conclusions The use of subanesthestic dose ketamine can significantly reduce the incidence of postoperative depression in cesarean section, and it has a good antidepressant effect.
