Research and clinical application advances in the pharmacogenomics of warfarin

VernacularTitle:华法林药物基因组学研究与临床应用进展
Author: Hanxue LI ¹ ; Tianyao LIU ; Shumei MA
Author Information

1. 中国医科大学附属盛京医院心血管内科
Keywords: Warfarin; Individualized medicine; Gene polymorphism; Review
From: Chinese Journal of Postgraduates of Medicine 2017;40(10):950-954
CountryChina
Language:Chinese
Abstract: Warfarin is widely used as an oral anticoagulant in clinic in China. It has narrow therapeutic index, large individual differences on dosage and the variability in warfarin dosage depends on many factors, including gene polymorphism, age, diet habits and so on. For clinicians, how to optimize the individual therapeutic regimen of warfarin is becoming a significant part of their work. In recent years, studies on genetic pharmacogenomics of warfarin are reported frequently. It is found that multiple gene polymorphisms can affect the efficacy of warfarin. We will introduce the gene polymorphism of some warfarin related genes and their effects on warfarin, and the advances of warfarin individual therapeutic regimen will also be discussed here.