Preparation of Oridonin-Single-Walled Carbon Nanotubes and Study on Its Adsorption Kinetics

VernacularTitle:冬凌草甲素-单壁碳纳米管载药体系的制备及其吸附动力学
Author: Xiaohong LIU ¹ ; Bohong GUO ; Danqiao XU ; Huanran QIU ; Jun YI
Author Information

1. 广东药科大学药学院
Keywords: Oridonin; Single-walled carbon nanotubes; Kinetics; adsorption
From: Herald of Medicine 2017;36(10):1170-1174
CountryChina
Language:Chinese
Abstract: Objective To investigate the method for preparing oridonin-single-walled carbon nanotubes ( ORI-SWCNTs) nanocomposite and study its adsorption kinetics. Methods ORI-SWCNTs nanocomposite was prepared by using the method of solution mixing. The synthesized ORI-SWCNTs nanocomposite was characterized by using Laser particle size analyzer, Fourier transform infrared, DSC analysis, powder X-ray diffraction and electron microscopy techniques. Results The encapsulation efficiency and loading capacity of ORI in SWCNTs-COOH nanocarrier was estimated to be about (70.23±2.1) %and (27.29±1.2) %, respectively. The Zeta potential was (-34.29±1.2) mV, partical size was about (458±18) nm. The absorption of ORI on SWCNTs-COOH could be explained by pseudo-second-order model. Conclusion The established preparation process of ORI-SWCNTs nanocomposite by solution mixing is feasible, with higher loading efficiency and encapsulate efficiency..