Low frequency repetitive nerve stimulation in anti-muscle specific tyrosine kinase receptor antibody positive myasthenia gravis
10.3760/cma.j.issn.1006-7876.2011.10.002
- VernacularTitle:骨骼肌特异性酪氨酸受体激酶抗体阳性重症肌无力的低频重复电刺激特点
- Author:
Ying TAN
1
;
Yuzhou GUAN
;
Li ZHU
;
Shuang WU
;
Qingyun DING
;
Youfang HU
;
Liying CUI
Author Information
1. 100730,中国医学科学院北京协和医院神经科
- Keywords:
Myasthenia gravis;
Receptors;
cholinergic;
Prostigmin;
Muscle-specific tyrosine kinase receptor
- From:
Chinese Journal of Neurology
2017;50(10):725-729
- CountryChina
- Language:Chinese
-
Abstract:
Objective To describe the repetitive nerve stimulation ( RNS) in anti-muscle specific tyrosine kinase (anti-MuSK) receptor antibody positive myasthenia gravis (MG), and compare with anti-acetylcholine receptor ( AChR ) positive myasthenia gravis , to figure out characteristics of anti-MuSK receptor MG.Methods We analyzed clinical and RNS data of nine anti-MuSK receptor MG and 19 age-and sex-matched anti-AChR MG.RNS was performed to the abductor digiti minimi , orbicularis oculi or musculus frontalis and trapezius .Results In anti-MuSK receptor MG , abnormal RNS in facial nerve was seen in 6/9 and in trapezius was 5/9, in limbs was 0.In anti-AChR MG, abnormal RNS in facial nerve was seen in 13/19, in trapezius was 18/19 and in limbs was 7/19.Abnormal in any of three parts was 8/9 and 19/19 in anti-MuSK receptor MG and anti-AChR MG, respectively.The RNS decrementing was more obvious in facial nerve in anti-Musk receptor MG than in anti-AChR MG.Negative prostigmin test was independently associated with anti-MuSK receptor MG (OR=4.25,95% CI 2.19 -15.25, P=0.015). Conclusions Abnormal RNS in any of three parts is more pronounced in anti-AChR MG compared with anti-MuSK receptor MG.RNS decrementing in facial nerve is more obvious in anti-AChR MG.Negative prostigmin test can aid in early suspicion in anti-MuSK receptor MG.
