Clinical significance of direct antiglobulin testing in anemia in patients with severe chronic hepatitis B
10.3969/j.issn.1671-9638.2017.10.003
- VernacularTitle:直接抗人球蛋白试验阳性在慢性重型乙型肝炎患者贫血中的临床意义
- Author:
yuan Wan QIN
1
;
Cheng MEI
;
Fang PENG
;
Juan WANG
;
ying Xiao ZHOU
;
rong Rong ZHOU
;
gong Xue FAN
;
Ning LI
Author Information
1. 中南大学湘雅医院
- Keywords:
hepatitis B;
chronic hepatitis B;
severe chronic hepatitis B;
direct antiglobulin testing;
red blood cell-related parameter;
anemia
- From:
Chinese Journal of Infection Control
2017;16(10):904-908
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate clinical significance of direct antiglobulin testing(DAT)in anemia in patients with severe chronic hepatitis B(CHB).Methods Red blood cell(RBC)-related parameters detection and DAT were performed among 30 healthy persons,30 CHB patients,and 50 severe CHB patients,clinical factors related to posi-tive DAT were analyzed.Results RBC count,hemoglobin (Hb)concentration,and hematocrit(HCT)level in severe CHB patients were all lower than CHB patients and healthy group(P <0.05),RBC distribution width(RDW)in severe CHB patients were all higher than CHB patients and healthy group(P<0.05);the positive rate of DAT in patients with se-vere CHB,CHB,and healthy group were 62.82%,13.33% and 0 respectively.RBC count,Hb concentration,and HCT level in severe CHB patients with positive DAT were all lower than severe CHB patients with negative DAT (all P <0.05),while RDW was higher than the latter (P=0.001);after RBC was separated through capillary,positive intensity of DAT of aged RBCs was higher than young RBCs in severe CHB patients (P <0.001);among severe CHB patients, DAT-positive and-negative patients differed in gender,age,alanine aminotransferase,total bilirubin,complement C3, C-reactive protein,and complication of diabetes(all P≤0.05).Conclusion Anemia in severe CHB patients may be re-lated to immune hemolysis of aged RBCs induced by antibody adsorption.
