Progresses of immunomodulatory therapy in sever acute pancreatitis
10.3760/cma.j.issn.2095-4352.2017.10.020
- VernacularTitle:重症急性胰腺炎免疫调节治疗的研究进展
- Author:
Guangming HE
1
;
Guanze XIONG
;
Song LU
;
Shanling XU
;
Keling CHEN
Author Information
1. 四川省肿瘤医院重症医学科
- Keywords:
Sever acute pancreatitis;
Imbalance of immune response;
Immunomodulatory therapy;
Inflammatory response
- From:
Chinese Critical Care Medicine
2017;29(10):954-957
- CountryChina
- Language:Chinese
-
Abstract:
Severe acute pancreatitis (SAP) is accompanied with complex pathogenic course and high mortality. The imbalance of immune response is an important cause which leads the SAP patients to the severe situation and even death. The immunomodulatory therapy can regulate the imbalance of inflammation, alleviate SAP-associated organ injury, and improve the prognosis of patients. Previous immunomodulatory therapy had some problems, such as single-object and simple-method. In recent years, some new methods of immunomodulatory therapy, such as regulating the apoptosis and mature of immune cells, applying of mesenchymal stem cells (MSCs) and multi-regulation methods, provide some new ideas and hopes for SAP therapy. This paper reviewed the history and recent research progresses of SAP immunomodulatory therapy.
