Prognostic analysis of 68 patients with initially diagnosed bone-only metastatic nasopharyngeal carcinoma
10.3760/cma.j.issn.1004-4221.2017.10.006
- VernacularTitle:68例首诊伴单纯骨转移鼻咽癌患者预后分析
- Author:
Dandan WANG
1
;
Mei LI
;
Zhining YANG
;
Xuejin SANG
;
Ren LUO
;
Zhenxi XU
;
Zhixiong LIN
Author Information
1. 大学医学院附属肿瘤医院放疗科
- Keywords:
Nasopharyngeal neoplasms/chemradiotherapy;
Neoplasm metastasis,bone;
Prognosis
- From:
Chinese Journal of Radiation Oncology
2017;26(10):1137-1140
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the prognostic factors in patients with initially diagnosed bone-only metastatic nasopharyngeal carcinoma (NPC). Methods We collected the data of 68 patients with initially diagnosed bone-only metastatic NPC admitted to The Affiliated Tumor Hospital of Shantou University Medical College from 1997 to 2015. Forty-nine patients received chemoradiotherapy. The Kaplan-Meier method was used to calculate the overall survival rate;the log-rank test was used for univariate prognostic analysis;the Cox model was used for multivariate prognostic analysis. Results The median follow-up was 953 months. The 1-, 2-, 3-, and 5-year overall survival ( OS) rates were 53%, 38%, 21%, and 15%, respectively. The median OS time was 134 months. The univariate prognostic analysis showed that spinal metastases, the number of bone metastases, lactic dehydrogenase level before treatment, the radiotherapy technology and dose for primary tumor, and the short-term outcome of primary tumor were associated with OS ( P=002, 001, 000, 002, 002, 001 ) . The multivariate prognostic analysis showed that ≤3 bone metastases, dose to primary tumor>65 Gy, and intensity-modulated radiotherapy ( IMRT) were favorable prognostic factors for OS ( P=003,002,004) . Conclusions For patients with initially diagnosed bone-only metastatic NPC, active treatment ( IMRT, dose to primary tumor>65 Gy) should be considered for those with ≤3 bone metastases to achieve a complete response of primary tumor.
