Research advances in the sphingosine kinase signaling pathway in liver fibrosis
10.3969/j.issn.1001-5256.2017.09.038
- VernacularTitle:鞘氨醇激酶信号通路在肝纤维化中的作用机制
- Author:
Yue SUN
1
;
Tian LAN
;
Jiao GUO
Author Information
1. 广东药科大学中医药研究院
- Keywords:
liver cirrhosis;
sphingosine kinase;
transforming growth factor beta1;
signal transduction;
review
- From:
Journal of Clinical Hepatology
2017;33(9):1798-1801
- CountryChina
- Language:Chinese
-
Abstract:
Formation of liver fibrosis mainly involves activation of hepatic stellate cell and imbalance between synthesis and degradation of extracellular matrix.The sphingosine kinase (SphK)/sphingosine 1-phosphate (S1P)/sphingosine 1-phosphate receptors (S1PRs) signaling pathway plays an important role in the regulation of cell life activities including proliferation,migration,and inflammatory response.This article introduces the distribution and biological functions of SphK,S1 P,and S1PRs and elaborates on the research advances in mechanism of action of the SphK/S1P/and S1PRs signaling pathway in liver fibrosis.Many studies have confirmed the important role of the SphK/S1P/and S1PRs signaling pathway in liver fibrosis,and in-depth exploration helps to provide new thoughts for clinical treatment of liver fibrosis and development of new drug targets.
