Comparison of iodixanol and iohexol on contrast-induced acute kidney injury in acute myocardial infarction patients undergoing emergent percutaneous coronary intervention
10.3969/j.issn.1004-8812.2017.09.004
- VernacularTitle:等渗或低渗对比剂对急诊经皮冠状动脉介入治疗术后急性肾损伤的影响
- Author:
Feng LONG
1
,
2
;
广州军区广州总医院心血管内科
;
xia Jin ZHANG
;
hua Zhi GONG
;
fei Yan WEN
;
ying Zhi CAO
;
sha Li XIA
;
di Hui LI
;
min Ai LI
;
cheng Ding XIANG
Author Information
1. 200433 上海,第二军医大学广州临床医学院
2. 广州军区广州总医院心血管内科
- Keywords:
Contrast-induced acute kidney injury;
Contrast-Induced Nephropathy;
Acute myocardial infarction;
Percutaneous coronary intervention
- From:
Chinese Journal of Interventional Cardiology
2017;25(9):491-497
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the incidence of contrast-induced acute kidney injury(CI-AKI) following iso-osmolar iodixanol or low-osmolar iohexol administration in patients with acute myocardial infarction(AMI)undergoing emergent percutaneous coronary intervention(PCI). Methods The study was a prospectiverandomized controlled study.Consecutive patients with AMI were assigned to either the iodixanol group or the iohexol group randomly after they were categorized in different group according to the infarcted walls(inferior and anterior infarction)indicated by electrocardiogram. The primary end point was the incidence of CI-AKI,which is defined as serum creatinine(sCr)increase>25% or>0.5 mg/dl(44 μmol/L)from baseline witin 72 hours. Results Two hundred ninety-seven patients were enrolled and allocated to the iodixanol group(n=149)or the iohexol group(n=148),and CI-AKI occurred in 22.1% of patients in the iodixanol group and 16.9% of patients in the iohexol group (95% confidence interval –14.2% to 3.8%,P for noninferiority<0.002). The incidence of CI-AKI was higher in the anterior infarction group than in the inferior infarction group(21.4% vs. 11.6%,P<0.01). Conclusions In patients with AMI who underwent emergent PCI,iohexol was not inferior to iodixanol on the incidence of CI-AKI,and it is reasonable to avoid selection bias for assigning patients into inferior and anterior infarction group according to the infarcted walls for the future CI-AKI related clinical study.
