Effects of lactobacillus on cholesterolemia and gut flora in hyperlipidemia mice

VernacularTitle:乳酸菌对高脂血症小鼠血脂和肠道菌的影响
Author: Wuhua WANG ¹ ; Cuiping WANG ; Shousong YUE
Author Information

1. 山东临沂罗庄中心医院检验科
Keywords: Lactobacillus; cholesterol; triglyceride; gut flora
From: Chinese Journal of Rehabilitation Medicine 2017;32(9):989-993
CountryChina
Language:Chinese
Abstract: Objective:To test the effects of natural lactobacillus bio-products on lipid metabolism and intestinal microflora.Method:A hyperlipidemia mouse model system was developed.30 hyperlipidemia mice were randomly divided into three equal groups,i.e,saline water (control treatment),lactobacillus cocktail,and simvastatin.Mice were injected daily with saline water,lactobacillus (L.plantarum,L.acidophilus and L.casei,mixture in equal volume),and simvastatin solution,respectively.Result:Significant lower total cholesterol (TC),triglyceride (TG),and low-density lipoprotein cholesterol (LDL-C) were found in the blood serum from mice treated with lactobacillus and pharmaceutical simvastatin.CFUs (colony forming unity) of lactobacillus were much higher (P ＜ 0.05),whereas CFUs of Escherichia coli and Enterococcus faecalis were much lower (P＜ 0.05 and P＜ 0.05,respectively) in mice feces of treated by lactobacillus compared to pharmaceutical simvastatin.Conclusion:Lactobacillus probiotics reduced levels of cholesterolemia,increased CFUs of lactobacillus and reduced CFUs of E.coli and E.faecalis in gut.