Role of DNA recognition receptors in pathogenic mechanism of hepatitis B
10.3969/j.issn.1001-5256.2017.09.037
- VernacularTitle:DNA识别受体在乙型肝炎发病机制中的作用
- Author:
Jin HUANG
1
;
Xiuqing PANG
;
Dongying XIE
Author Information
1. 中山大学附属第三医院肝病实验室
- Keywords:
hepatitis B;
receptors,pattern recognition;
review
- From:
Journal of Clinical Hepatology
2017;33(9):1794-1797
- CountryChina
- Language:Chinese
-
Abstract:
As a global disease,hepatitis B still threatens human health.However,the pathogenesis of hepatitis caused by HBV remains unclear.The innate immune system in the liver can detect HBV infection and use every strategy to eliminate the virus.DNA recognition receptors play an important role in this process;they recognize tlBV DNA or pgRNA in cytoplasm or nucleus,activate innate immunity through various signaling pathways to produce inflammatory cytokines and interferon,and finally exert their antiviral effect.This article summarizes the DNA recognition receptors involved in inflammation induced by HBV and HBV clearance,elaborates on their detailed pathways,and discusses the issues regarding the role of DNA recognition receptors in liver innate immunity induced by HBV and related perspectives.
