Depression and Its Severity Are Strongly Associated with Both Storage and Voiding Lower Urinary Tract Symptoms Independently of Prostate Volume.
10.3346/jkms.2015.30.11.1646
- Author:
Su Min JEONG
1
;
Beomseok SUH
;
Soo Hyun JANG
;
Ho Seong JIN
;
Nakhyun KIM
;
Hyuktae KWON
;
Belong CHO
;
Jin Ho PARK
Author Information
1. Department of Family Medicine, Seoul National University Hospital, Seoul, Korea. kkolzzi0@gmail.com
- Publication Type:Original Article
- Keywords:
Depression;
Beck Depression Inventory;
Lower Urinary Tract Symptoms;
International Prostate Symptom Score;
Prostate Volume
- MeSH:
Adult;
Age Distribution;
Aged;
Aged, 80 and over;
Comorbidity;
Depression/*diagnosis/*epidemiology;
Humans;
Incidence;
Lower Urinary Tract Symptoms/*diagnosis/*epidemiology;
Male;
Men's Health/statistics & numerical data;
Middle Aged;
Organ Size;
Prostate;
Prostatic Hyperplasia/*diagnosis/*epidemiology;
Republic of Korea/epidemiology;
Risk Factors;
Severity of Illness Index
- From:Journal of Korean Medical Science
2015;30(11):1646-1651
- CountryRepublic of Korea
- Language:English
-
Abstract:
Depression is related to various functional medical conditions. Its association with lower urinary tract symptoms (LUTS) is also expected. We evaluated whether depression and its severity are associated with LUTS when LUTS risk factors including prostate volume (PV) are taken into account in a large population of Korean men. Study subjects included 10,275 men who underwent routine health check-ups at the Healthcare System Gangnam Center of Seoul National University Hospital. Depression was assessed using Beck Depression Inventory-II and LUTS using international prostate symptom score. PV was measured using transrectal ultrasonography by a radiologist. Effect sizes of depression severity on total, storage, and voiding symptoms were assessed. In multivariate logistic regression analysis, mild, moderate and severe depression were associated with total (adjusted odds ratio: aOR = 2.99, 3.86 and 8.99; all P < 0.001), voiding (aOR = 3.04, 3.28 and 5.58; all P < 0.001) and storage symptoms (aOR = 2.43, 3.43 and 2.89; all P < 0.05) showing dose response relationships (all P trend < 0.001). In a subgroup analysis for participants with PV data (n = 1,925), mild and moderate-severe depression were also associated with LUTS (aOR = 3.29, 2.84; P < 0.001 and 0.018, respectively). In conclusion, depression and its severity are strongly associated with total, voiding, and storage symptoms independently of PV state.
