Effects of Shenge Powder on heart function in rats with heart failure by coarctation of abdominal aorta
10.3969/j.issn.1001-1528.2017.09.002
- VernacularTitle:参蛤散对腹主动脉缩窄心力衰竭大鼠心功能的影响
- Author:
yan Ling ZHU
1
;
hong Yi WEI
;
Juan YANG
;
xiao Yun LIN
;
Min CAO
;
hua You WANG
;
yun Su YUAN
;
Duan ZHOU
Author Information
1. 上海中医药大学附属龙华医院
- Keywords:
Shenge Powder;
heart failure;
PGC-1αt;
mitochondria
- From:
Chinese Traditional Patent Medicine
2017;39(9):1766-1770
- CountryChina
- Language:Chinese
-
Abstract:
AIM To investigate the effects of Shenge Powder (Ginseng Radix et Rhizoma,Gecko) on heart function in rats with heart failure by coarctation of abdominal aorta and its mechanism of action.METHODS The heart failure rats were fed with Shenge Powder [1.89 g/(kg · d)] or bisoprolol [1 mg/(kg · d)] for twelve weeks.The pathological morphology,hemodynamics,cardiographic index and effect on protein expression of PGC-1 α in sham operation group,model group,Shenge Powder group and Bisoprolol group were observed.RESULTS Compared with the model group,Shenge Powder increased ejection fraction (EF) (P ＜ 0.05),decreased left ventricular end-diastolic pressure (LVEDP) (P ＜ 0.01),improved maximal rate of left ventricular pressure development (dp/dtmax) and maximal rate of left ventricular pressure decay (dp/dtmin) (P ＜ 0.01),reduced myocardial tissue lesions and myocardial fibrosis.There was no significant difference in PGC-1α protein expression between the Shenge Powder group and the model group.CONCLUSION Shenge Powder can improve left ventricular function in rats with heart failure,and reduce the pathological changes of myocardium tissue.
