Roles of endoplasmic reticulum stress in early brain injury after subarachnoid hemorrhage
10.3760/cma.j.issn.1673-4165.2017.07.013
- VernacularTitle:内质网应激在蛛网膜下腔出血后早期脑损伤中的作用
- Author:
Wentao QI
1
;
Yongkang WU
Author Information
1. 225001,扬州大学附属医院神经外科
- Keywords:
Subarachnoid Hemorrhage;
Brain Injuries;
Endoplasmic Reticulum Stress;
Autophagy;
Apoptosis;
Inflammation
- From:
International Journal of Cerebrovascular Diseases
2017;25(7):655-659
- CountryChina
- Language:Chinese
-
Abstract:
Spontaneous subarachnoid hemorrhage (SAH) is a common acute cerebrovascular disease with high morbidity and mortality in clinical practice.Recent studies have shown that early brain injury (EBI)would occur within 72 h after SAH,and is closely associated with the poor outcome in patients with SAH.There are many possible mechanisms resulting in EBI,such as inflammation,autophagy,apoptosis.These damage mechanisms are all associated with endoplasmic reticulum stress.This article reviews the roles of endoplasmic reticulum stress in EBI after SAH.
