Long-term clinical study of effects of hemodialysis combined with hemoperfusion on clearance of protein-bound uremic toxins in maintenance hemodialysis patients
10.7644/j.issn.1674-9960.2017.07.013
- VernacularTitle:血液透析联合血液灌流治疗对清除维持性血液透析患者体内蛋白结合类毒素的长期临床研究
- Author:
qiang Zhi OU
1
;
de Li LUN
;
lun Xin LI
;
Jian LI
;
fang Gui DOU
Author Information
1. 河北北方学院研究生院
- Keywords:
protein-bound uremic toxins;
hemoperfusion;
hemodialysis;
high-performance liquid chromatography/tandem mass spectrometry
- From:
Military Medical Sciences
2017;41(7):611-614
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effects of long-term hemodialysis(HD) combined with hemoperfusion(HP) on the levels of protein-bound uremic toxins (PBUTs) in maintenance hemodialysis (MHD) patients.Methods Forty-six patients with MHD were selected and divided into HD +HP group and HD group .HD+HP group ( n=22 ) was treated with low-flux HD twice a week and HD combined with HP once a week ,while HD group(n=24) was treated with low-flux HD three times a week.The follow-up lasted 36 weeks.The pre-dialysis concentration of PBUTs was measured at week 12, 24, 36 and baseline.PBUTs included hippuric acid (HA), indoxyl sulphate (IS)and p-cresyl sulphate (PCS).High performance liquid chromatography-tandem mass spectrometry ( HPLC-MS/MS) was used for determination .Results After 36 weeks of follow-up, the concentration of the three toxins in the HD +HP group was lower than that in the HD group during the study.At the end of the study, the reduction rates of HA, IS and PCS were 33.5%,12.8% and 24.2%, respectively, in HD+HP group.The three toxins in HD group increased by 2.3%,21.8%and 2.8%.The clearance rate of HA, PCS and IS in the HP+HD group was higher than in HD group (P<0.05).Conclusion Long-term HD combined with HP can more effectively remove PBUTs , and keep them at a lower level .
