Effects of ACE2/Apelin signaling on vascular autophagy regulation and hypertension pathogenesis
10.3969/j.issn.1674-8115.2017.09.012
- VernacularTitle:ACE2/Apelin信号在血管自噬调控和高血压发病中的作用
- Author:
Yan ZHANG
1
;
wen Yu CHENG
;
chang Jiu ZHONG
Author Information
1. 上海市高血压研究所
- Keywords:
hypertension;
renin-angiotensin system;
autophagy;
angiotensin Ⅱ
- From:
Journal of Shanghai Jiaotong University(Medical Science)
2017;37(9):1260-1264
- CountryChina
- Language:Chinese
-
Abstract:
Autophagy provides protective effects on the maintenance of normal vascular structure and function. However, an overactivation of autophagy contributes to the pathogenesis of hypertension and other vascular diseases. The imbalance of vascular autophagy is involved in the occurrence and development of hypertensive vascular remodeling and injury, which is closely related to abnormal expression or activity of ACE2/Apelin signaling. This review will focus on the latest advancement and regulatory roles of ACE2/Apelin signaling in vascular autophagy and the pathogenesis of hypertension.
