Effect of autophagy on epithelia-mesenchymal transition

VernacularTitle:自噬在肿瘤上皮间质转化中的作用
Author: ning Bo LI ¹ ; mei Dong LAI
Author Information

1. 上海交通大学医学院附属国际和平妇幼保健院
Keywords: autophagy; epithelial-mesenchymal transition; hypoxia-inducible factor 1; p62
From: Journal of Shanghai Jiaotong University(Medical Science) 2017;37(9):1270-1274
CountryChina
Language:Chinese
Abstract: Autophagy is a self-renewing cellular process by which defective proteins and aged organs are eliminated. It is noteworthy that autophagy correlates with the initiation and progression of cancer. During epithelial-mesenchymal transition (EMT), cells with epithelial phenotype gain mesenchymal characteristics, thus facilitate invasion and metastasis. Autophagy may suppress EMT by the following mechanisms, such as decreasing hypoxia inducible factor-1 (HIF-1) in hypoxia to downregulate transcription of EMT related genes, regulating TGF-β/Smad signaling pathway negatively, utilizing selective autophagy adaptor, p62, to modulate EMT transcription factors. Further studies of the association between autophagy and EMT may contribute to indentify new targets of cancer therapy.