Progress in genetics of autoimmune hepatitis
10.3969/j.issn.1674-8115.2017.09.017
- VernacularTitle:自身免疫性肝炎遗传学研究进展
- Author:
ran Yi WEI
1
;
Xiong MA
;
qi Ru TANG
Author Information
1. 上海市消化疾病研究所
- Keywords:
autoimmune hepatitis;
human leukocyte antigen;
genome-wide association study
- From:
Journal of Shanghai Jiaotong University(Medical Science)
2017;37(9):1286-1290
- CountryChina
- Language:Chinese
-
Abstract:
Autoimmune hepatitis (AIH) is an autoimmune liver disorder characterized by chronic inflammation of liver. Although the etiology of AIH remains obscure, genetic and environmental factors may contribute to the development of AIH. In the past years, investigators have attempted to uncover the genetic architecture of AIH. Multiple genetic loci have been reported to be associated with AIH, in which human leukocyte antigen (HLA) alleles were strongly associated with disease onset and clinical manifestations for decades. A recent genome wide association study identified that two loci (SH2B3 and CARD10) increased susceptibility of AIH, in addition to the HLA loci. The genetic study is aiming to help to elucidate the genetic pathogenesis for AIH.
