Mechanisms of probiotics to improve type 2 diabetes mellitus
10.3969/j.issn.1674-8115.2017.09.021
- VernacularTitle:益生菌改善2型糖尿病的相关机制
- Author:
lin Xue LI
1
;
yun Yan GU
;
fei Yi ZHANG
Author Information
1. 上海交通大学 医学院附属瑞金医院内分泌代谢病科
- Keywords:
type 2 diabetes mellitus;
probiotics;
intestinal flora;
short chain fatty acids;
bile acids
- From:
Journal of Shanghai Jiaotong University(Medical Science)
2017;37(9):1308-1314
- CountryChina
- Language:Chinese
-
Abstract:
There are tens of thousands of microbiota in the intestine, and the balance of these microbiota is essential to maintain intestinal stability and body metabolism. Once the intestinal flora structure is disordered, a variety of metabolic diseases will follow. In recent years, the international scientific researches focus on the relationship between intestinal flora and metabolic diseases, especially type 2 diabetes mellitus (T2DM). And the probiotics, as a kind of active microorganism that regulate the micro-ecological balance of the host's gut, can change the intestinal flora and their metabolites, and thus improve the host energy metabolism and reduce low level chronic inflammation and oxidative stress. Therefore, its intake has gradually become an usual method of preventing and controlling T2DM. This review provides an overview of the effects of probiotics on host intestinal flora and the mechanisms of improving T2DM, as well as a theoretical reference for the clinical application of probiotics.
