Application and development of genetic knockout animal models in researches of obsessive-compulsive disorder

VernacularTitle:基因敲除动物模型在强迫症研究中的应用与进展
Author: Pei WANG ¹ ; ting Ting XU ; Qing ZHAO ; Zhen WANG
Author Information

1. 上海交通大学医学院附属精神卫生中心
Keywords: obsessive-compulsive disorder; animal model; gene knockout
From: Journal of Shanghai Jiaotong University(Medical Science) 2017;37(9):1291-1295
CountryChina
Language:Chinese
Abstract: Recently, some progress has been made in the clinical study of obsessive compulsive disorder (OCD). Human research has inherent limitation because of its non-invasive nature, while animal models can break through the shortcomings of human research, allowing us to more accurately study the pathophysiology of OCD. Therefore, many researchers tried to use genetic knockout animal models to further study the etiology of OCD. In this review, recent progress about this kind of research was reviewed.