Clinical Observation of Memantine Hydrochloride Tablets Combined with Tianzhi Granules in the Treat-ment of Vascular Dementia
10.6039/j.issn.1001-0408.2017.29.21
- VernacularTitle:盐酸美金刚片联合天智颗粒治疗血管性痴呆的临床观察
- Author:
Shengtao WU
1
;
Yu ZHANG
;
Fuhui LI
;
Baochao ZHANG
Author Information
1. 南阳市中心医院神经内科
- Keywords:
Memantine hydrochloride tablets;
Tianzhi granules;
Vascular dementia;
Therapeutic efficacy;
Scale scoring;
Brain-derived neurotrophic factor;
Malondialdehyde;
Superoxide dismutase
- From:
China Pharmacy
2017;28(29):4109-4112
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the clinical efficacy and safety of Memantine hydrochloride tablets combined with Tianzhi granules in the treatment of vascular dementia. METHODS:A total of 94 patients with vascular dementia selected from our hospital during Jun. 2014-Jun. 2016 were divided into observation group and control group according to random number table,with 47 cases each. Besides basic therapy,control group was given Tianzhi granules 5 g,po,tid. Observation group was additionally given Memantine hydrochloride tablets with initial dose of 5 mg,increasing by 5 mg every week,maintaining dose of 20 mg/d at 4th week,po,qd,on the basis of control group. Both groups received treatment for consecutive 4 weeks. Clinical efficacies as well as MMSE,MoCA,ADL scores,the levels of brain-derived neurotrophic factor(BDNF),malondialdehyde(MDA)and super-oxide dismutase(SOD)before and after treatment were observed in 2 groups.The occurrence of ADR was recorded.RESULTS:To-tal response rate of observation group(80.85%)was significantly higher than control group(61.70%),with statistical significance (P<0.05). Before treatment,there was no statistical significance in MMSE,MoCA,ADL scores,the levels of BDNF,MDA or SOD between 2 groups(P>0.05).After treatment,MMSE,MoCA,ADL scores,the levels of BDNF and SOD in 2 groups were increased significantly,while MDA level was decreased significantly;observation group was significantly better than control group,with statistical significance(P<0.05). No obvious ADR was found in 2 groups. CONCLUSIONS:Memantine hydrochlo-ride tablets combined with Tianzhi granules in the treatment of vascular dementia show significant therapeutic efficacy,and can im-prove cognitive function,daily living activity and BDNF,MDA and SOD levels of patients with good safety.
