Relationship of TAZ expression between peripheral blood and tumor tissue in patients with colorectal cancer and its clinical significance
10.3969/j.issn.1671-8348.2017.28.009
- VernacularTitle:结直肠癌患者外周血与肿瘤组织中TAZ表达的关系及临床意义研究
- Author:
Aijun WANG
1
;
Hongyu WANG
;
Jinheng XU
;
Baojun ZHENG
;
Xiao WU
;
Jian CHENG
;
Chao ZHANG
;
Hua SHI
;
Junwei FENG
Author Information
1. 河北医科大学附属唐山市工人医院肿瘤外科 063000
- Keywords:
colorectal neoplasms;
TAZ;
recurrence;
tumor markers
- From:
Chongqing Medicine
2017;46(28):3915-3916,3919
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of TAZ in peripheral blood and tumor tissue of the patients with colorectal cancer and to analyze their relationship and clinical significance.Methods Eighty-five cases of pathologically verified colorectal cancer treated by radical operation were selected as the operation group,and 35 cases with postoperative relapse served as the recurrent group.Meanwhile 50 age and sex-matched healthy persons were selected as the control group.The immunohistochemical(SP)technique was adopted to detect the expression of TAZ in tumor tissues and expression of TAZ in peripheral blood was tested with enzyme linked immunosorbent assay(ELISA).Results The level of preoperative TAZ in peripheral blood of the operation group was significantly higher than that of the control group(P＜0.05).The level of peripheral blood TAZ after operation in the operation group had no significant change compared with the control group (P＞0.05).The level of peripheral blood TAZ in the recurrent group was significantly higher than preoperative level of operation group(P＜0.05).The expression of tumor tissue TAZ was significantly higher than that of normal mucosal tissue(P＜0.05);the expression of tumor tissue TAZ in the recurrent group was higher than that in the operation group(P＜0.05).The tumor tissue TAZ level in the operation group and recurrent group had obvious correlation with peripheral blood TAZ level(P＜0.05).Conclusion Monitoring the TAZ level has obvious reference value for predicting colorectal cancer staging and timely understanding tumor recurrence.
