Research progress on tumor chemotherapy combined with photodynamic therapy and immunotherapy
10.3760/cma.j.issn.1673-4181.2017.04.008
- VernacularTitle:肿瘤化疗协同光动力疗法联合免疫治疗的研究进展
- Author:
Fan FAN
1
;
Dunwan ZHU
;
Linhua ZHANG
Author Information
1. 300192天津,中国医学科学院北京协和医学院生物医学工程研究所,天津市生物医学材料重点实验室
- Keywords:
Tumor;
Chemotherapy;
Photodynamic therapy;
Immunotherapy;
Combination therapy
- From:
International Journal of Biomedical Engineering
2017;40(4):262-268,后插5-后插6
- CountryChina
- Language:Chinese
-
Abstract:
In recent years,the incidence of malignant tumors continually increased with the trend of younger age in onset age,which pose a serious threat to human health.At present,there are a variety of clinical anti-tumor treatments.However,a single treatment usually cannot achieve the best therapeutic effect.As a result,the combination therapy is often used in clinical practice.Combination therapy not only can enhance the therapeutic effect and reduce the toxic side effects of drugs,but also can alleviate the pain of patients.Chemotherapy is a commonly used clinical treatment for tumors.However,it can lead to greater side-effects,and cause irreversible damage to normal cells while killing the tumor cells.Photodynamic therapy uses the specific wavelengths of light to excite and activate the photosensitizer enriched in the tumor local.As a result,the tumor cells are killed directly or indirectly by photodynamic reactions with the participation of internal oxygen.Tumorassociated antigen will appear following the chemotherapy or photodynamic therapy.The immune system will stimulate the body to produce specific anti-tumor immune response after identifying the tumor-associated antigens.The combination treatment of chemotherapy and photodynamic therapy combined with immunotherapy not only can effectively improve the treatment effect of chemotherapy drugs and reduce drug side effects,inhibit tumor metastasis,but also can induce the production long-term anti-tumor immune response,so as to maximize the treatment effect.In this paper,the progress of the researches on chemotherapy,photodynamic therapy and immunotherapy in recent years were summarized.
