Research progress on nanoparticles as delivery systems for cancer immunotherapy
10.3760/cma.j.issn.1673-4181.2017.04.009
- VernacularTitle:基于纳米递送系统的肿瘤免疫治疗研究进展
- Author:
Fengqiang CAO
1
;
Mengmeng YAN
;
Xiaoxuan LIU
;
Jing ZHANG
;
Hai WANG
;
Lanxia LIU
;
Guilei MA
Author Information
1. 中国医学科学院北京协和医学院生物医学工程研究所
- Keywords:
Cancer;
Immunotherapy;
Vaccine;
Nanoparticles delivery system
- From:
International Journal of Biomedical Engineering
2017;40(4):269-274
- CountryChina
- Language:Chinese
-
Abstract:
In recent years,cancer immunotherapy has developed rapidly due to its significant advantages compared with the traditional cancer treatment methods.Tumor immunotherapy aims at mobilizing or stimulating the body's own immune function,thereby inhibiting and killing cancer cells.With the development of nanotechnology,biological nano-carrier materials provide a new insight into the vaccine development.Nano-vaccines are therapeutic or prophylactic vaccines based on nanotechnology including exogenous antigens for inducing immune responses,vectors delivering antigens,and adjuvants for enhancing immunogenicity and accelerating and prolonging the availability of cancer vaccines.Nano-delivery vectors have good biocompatibility as well as unique physical and chemical properties.They can effectively deliver the antigens,and further activated the immune response of antigenspecific cellulars based on the activation of the body's humoral immunity by regulating the presentation pathways in the antigen-presenting cells.In this paper,the applications of nano-delivery systems in cancer vaccine research were summarized.
