Study on Inclusion Behavior and Properties of Cordycepin with Hydroxypropyl-β-Cyclodextrin
10.11895/j.issn.0253-3820.170269
- VernacularTitle:虫草素与羟丙基-β-环糊精的包合行为及性能研究
- Author:
Fang ZHAO
1
;
Qiu Xue ZHAO
;
Qing CHANG
;
Hui Shu WANG
;
Yao DU
;
Juan Li YANG
Author Information
1. 云南民族大学化学与环境学院
- Keywords:
Cordycepin;
Hydroxypropyl-β-cyclodextrin;
Inclusion complex;
Solubility;
Stability
- From:
Chinese Journal of Analytical Chemistry
2017;45(10):1547-1555
- CountryChina
- Language:Chinese
-
Abstract:
The inclusion complex of cordycepin ( COR ) with hydroxypropyl-β-cyclodextrin ( HPβCD ) was prepared by the method of saturated solution. The inclusion of HPβCD with COR in aqueous solution was studied by UV-vis spectroscopy, and the inclusion ratio of COR/HPβCD complex was determined with the Job plots. The COR/HPβCD complex was characterized and determined by means of 1 H NMR and 2D NMR, differential scanning calorimetry ( DSC ) , thermogravimetric analysis ( TG ) , X-ray diffraction ( XRD ) , Fourier transform infrared spectroscopy ( FTIR) and scanning electron microscope ( SEM) . The results showed that the COR/HPβCD complex ratio was 1:1 and the water solubility and stability of COR were obviously increased in the inclusion complex with HPβCD. The COR/HPβCD complex will be potentially useful for its medical application.
