Influence of gut microbiota on the development of tumor via the gut-brain axis
10.3969/j.issn.1000-8179.2017.17.160
- VernacularTitle:肠道菌群通过脑肠轴影响肿瘤的发生发展
- Author:
XU JING
1
;
LIU QIYU
;
LI KE
;
KANG YU
;
XU CONGJIAN
Author Information
1. 复旦大学附属妇产科医院中西医结合科 上海市200011
- Keywords:
gut microbiota;
gut-brain axis;
chronic stress;
tumor
- From:
Chinese Journal of Clinical Oncology
2017;44(17):886-889
- CountryChina
- Language:Chinese
-
Abstract:
Under normal circumstances, the gut microbiota and the proportion of symbiotic bacteria, probiotics, and pathogens re-main relatively stable, but dysbiosis in the gut can change not only the physiological environment of the intestine but also the physio-logical state of some distant tissues and organs. This condition can even lead to tumor development. Gut-brain axis is a pathway through which gut microbiota can influence tumor growth and is associated with other pathways, such as immune, metabolic, neuro-endocrine, and vagal neural pathways. This paper reports the relationship between tumor growth and microbial groups in the gut and the mechanisms of gut dysbiosis inducing a chronic stress state via the gut–brain axis, which affects tumor development. This paper also presents the role of gut microbiota in tumor treatment.