Influence of gut microbiota on the development of tumor via the gut-brain axis

VernacularTitle:肠道菌群通过脑肠轴影响肿瘤的发生发展
Author: XU JING ¹ ; LIU QIYU ; LI KE ; KANG YU ; XU CONGJIAN
Author Information

1. 复旦大学附属妇产科医院中西医结合科上海市200011
Keywords: gut microbiota; gut-brain axis; chronic stress; tumor
From: Chinese Journal of Clinical Oncology 2017;44(17):886-889
CountryChina
Language:Chinese
Abstract: Under normal circumstances, the gut microbiota and the proportion of symbiotic bacteria, probiotics, and pathogens re-main relatively stable, but dysbiosis in the gut can change not only the physiological environment of the intestine but also the physio-logical state of some distant tissues and organs. This condition can even lead to tumor development. Gut-brain axis is a pathway through which gut microbiota can influence tumor growth and is associated with other pathways, such as immune, metabolic, neuro-endocrine, and vagal neural pathways. This paper reports the relationship between tumor growth and microbial groups in the gut and the mechanisms of gut dysbiosis inducing a chronic stress state via the gut–brain axis, which affects tumor development. This paper also presents the role of gut microbiota in tumor treatment.