Effects of inflammatory response and postoperative analgesia on thoracic paravertebral nerve block in pa-tients undergoing radical resection of lung cancer
10.3969/j.issn.1006-5725.2017.18.018
- VernacularTitle:胸椎旁神经阻滞对肺癌根治术患者炎性反应和术后镇痛效果的影响
- Author:
Dashun LIANG
1
;
Lixing LIAO
;
Jinliang CAO
;
Caidie CAI
;
Zhuren WEN
;
Min LI
Author Information
1. 广东省农垦中心医院麻醉科
- Keywords:
thoracic paravertebral nerve block;
radical resection of lung cancer;
inflammatory response;
postoperative analgesia
- From:
The Journal of Practical Medicine
2017;33(18):3051-3054
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the Effects of inflammatory response and postoperative analgesia on thoracic paravertebral nerve block in patients undergoing radical resection of lung cancer. Methods In this study, 68 patients with radical resection of lung cancer were divided into observation group(34 cases)and control group (34 cases)randomly. The anesthesia method of the observation group was general anesthesia combined with thorac-ic paravertebral nerve block ,and the anesthesia method of control group was general anesthesia. Serum IL-6 and IL-10 concentrations were measured before anesthesia(T0),30 min after surgery starts(T1),surgery end(T2),6h after surgery(T3). The visual analogue score of 2 h,12 h,24 h and 48 h postoperatively in two groups were re-corded. The postoperative 24h sufentanil dosage,the number of PCIA pump pressure and the total amount of back-ground infusion were measured. Results Compared with the control group,the serum IL-6 level of T2 and T3 in the observation group were significantly lower than those of the control group ,while the IL-10 concentration was significantly higher in the observation group(P<0.05). The VAS scores of 2 h,12 h and 24 h in the observation group were significantly lower than those in the control group(P<0.05). The 24h sufentanil dosage,PCIA pump pressure and the total amount of background infusion in the observation group were significantly lower than those in the control group(P < 0.05). Conclusions Preoperative thoracic paravertebral nerve block can significantly re-duce the inflammatory response and enhance postoperative analgesia.
