The effect of ketamine on the postoperative depression-like mood and inflammatory mediators during one lung ventilation in patients with esophageal cancer radical surgery
10.3969/j.issn.1006-5725.2017.18.028
- VernacularTitle:小剂量氯胺酮对食道癌根治术患者单肺通气期间炎症介质及术后抑郁样情绪的影响
- Author:
Junchao DAI
1
;
Xiaobin WANG
;
Maohua WANG
Author Information
1. 西南医科大学附属医院麻醉科
- Keywords:
ketamine;
esophageal cancer radical surgery;
inflammatory mediators;
postoperative depression-like mood
- From:
The Journal of Practical Medicine
2017;33(18):3089-3092
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of ketamine at low dose on inflammatory mediators during one lung ventilation and postoperative depression-like mood in patients with esophageal cancer radical surgery. Methods 60 patients who underwent esophageal cancer radical surgery were randomly divided into ketamine group(K)and control group(C). The patients in group K was injected with ketamine at a dose of 0.5 mg/kg at the time of anesthesia induction,then continuous infused with ketamine at a dose of 0.25 mg/(kg · h)for 30 minutes. Patients in group C:saline was given .Then concentrations of TNF-α,IL-6,IL-10 and PHQ-9 scores at different time points were evaluated. Results The PHQ-9 scores of the patients in K group at the 5 d after operation was significantly lower than that at the 1d before operation(P<0.05);The PHQ-9 scores in group K were decreased ob-viously than that those in group C(P<0.05). The concentration of serum TNF-α,IL-6 and IL-10 were significantly increased after T1 time of the two groups(P<0.05);Compared with group C,there was no statistical difference in the levels of TNF-α,IL-6 and IL-10 in group K at T2 and T3 time(P<0.05).Conclusion Low dose ketamine has no obvious effect on the concentration of blood TNF-α,IL-6 and IL -10 during one lung ventilation in patients with esophageal cancer radical surgery ,but it may alleviate postoperative depression-like mood.
