Efficacy and safety of long-term use of low dose glucocorticoids in acute respiratory distress syndrome
10.3969/j.issn.1006-5725.2017.18.029
- VernacularTitle:低剂量长疗程糖皮质激素治疗急性呼吸窘迫综合征的效果及安全性研究
- Author:
Jiaxin SHI
1
;
Jiashu LI
;
Xiaomei LI
;
Xiangjun GUO
;
Feng ZHANG
;
Junfa YANG
;
Man ZHANG
;
Wen HUO
Author Information
1. 222002 江苏省连云港市第一人民医院,徐州医科大学附属连云港医院,南京医科大学连云港临床医学院,江苏大学连云港临床医学院呼吸内科
- Keywords:
Acute respiratory distress syndrome;
Glucocorticoids;
Low dose;
Efficacy;
Safety
- From:
The Journal of Practical Medicine
2017;33(18):3092-3095
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the ef fi cacy and safety of long-term use of low dose glucocorticoids in acute respiratory distress syndrome (ARDS). Methods Fifty ARDS patients were randomly divided into two groups. The control group(25 patients)received non-invasive or invasive mechanical ventilation,antibiotics and support treatments. The glucocorticoids group(25 patients)received the same treatments plus long-term use of low dose glucocorticoids. Results The mortality in glucocorticoids group(32％(8/25))was much lower than that in the control group(60％(15/25))(P < 0.05). The ventilator-free days and organ failure-free days within 28d in glucocorticoids group were significantly higher than those in the control group (P < 0.05). The oxygenation index and the serum IL-8 levels in glucocorticoids group at 14d and 28d were higher than those in the control group(P<0.05). Compared to the control group ,long-term use of low dose glucocorticoids in ARDS did not increase fasting blood-glucose at 7d,gastrointestinal bleeding and hospital infections within 28d. Conclusions Long-term use of low dose glucocorticoids in ARDS could reduce the serum IL-8 levels and improve the prognosis.
