Relationship between the use of carvedilol and the improvement of survival of patients with liver cirrhosis ascites
10.3969/j.issn.1006-5725.2017.18.031
- VernacularTitle:卡维地洛的使用与肝硬化腹水患者生存改善的相关性
- Author:
Hongyan LI
1
;
Guo WANG
;
Zhuang WANG
;
Weiliang KE
;
Yi YU
Author Information
1. 广东医科大学附属医院消化内科
- Keywords:
carvedilol;
propranolol;
liver cirrhosis;
ascites
- From:
The Journal of Practical Medicine
2017;33(18):3099-3102
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of carvedilol on survival improvement in patients with liver cirrhosis and ascites. Methods A retrospective cohort study was conducted by following up the patients with liver cirrhosis and ascites,the patients were treated in our hospital from March 1st,2010 to March 1st,2011. One hun-dred and fifty eight patients were enrolled and followed up for 5 years to determine the survival status. Patients were divided into the carvedilol group and the propranolol group based on the use of the therapeutic drugs. The baseline , treatment and follow-up data were compared ,and the survival status of patients in two groups were described by the survival curve. The factors influencing the survival of patients with liver cirrhosis ascites were analyzed by the Cox proportional hazards model. Results The age,BMI,HVPG reduction and the prevalence of diabetes in the carve-dilol group were higher than those in the propranolol group ,but upper gastrointestinal variceal re-bleeding rate was lower than that in the propranolol group,with significant differences(P < 0.05,respectively). Kaplan Meier sur-vival function showed that the cumulative survival rate of the carvedilol group was higher than that of the proprano-lol group(P<0.05). Cox regression result showed that hazard ratio of RR=0.714,95％CI(0.565～0.902),P=0.013. Conclusion Carvedilol is a protective factor for patients with liver cirrhosis and ascites ,contributing to im-proving the survival status ,reducing liver cirrhosis related deaths.
