Application of alpha-enolase combined with CYFRA21-1 and CA125 in diagnosis of malignant pleural effu-sion
10.3969/j.issn.1006-5725.2017.18.035
- VernacularTitle:α-烯醇化酶联合CYFRA21-1、CA125在恶性胸腔积液诊断中的应用
- Author:
Rufang LI
1
,
2
;
云南省第一人民医院呼吸内科
;
Jianqing ZHANG
;
Xuming WANG
;
Jianghai WU
;
Jiagang FENG
;
Zhihuan ZHAO
Author Information
1. 650032 昆明医科大学第一附属医院呼吸内二科
2. 云南省第一人民医院呼吸内科
- Keywords:
alpha-enolase;
pleural effusion;
CYFRA21-1;
CA125
- From:
The Journal of Practical Medicine
2017;33(18):3114-3118
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the concentrations of alpha-enolase (ENO1),CYFRA21-1,and CA125 in the patients with malignant pleural effusion ,tuberculous exudative pleural effusion ,or parapneumonia pleural effusion. To explore the clinical value of ENO1 in pleural effusion combined with serum CYFRA21-1 and CA125 in diagnosis of malignant pleural effusion. Methods Enzyme-linked immunosorbent assay(ELISA)was used to detect the concentration of ENO1 in pleural effusions. The concentrations of CA125 and CYFRA21-1 in the blood samples were measured using chemiluminescence and magnetic particle-based chemiluminescence respective-ly. The sensitivity and specificity of ENO1 combined with serum CYFRA21-1 and CA125 detection were calculated. Results The concentration of ENO1 in malignant pleural effusion group was significantly increased(P<0.001);the concentrations of ENO1 did not differ significantly between tuberculous exudative pleural effusion and parapneu-monia pleural effusion(P>0.05). The sensitivity and specificity of ENO1 combined with serum CYFRA21-1 and CA125 detection in malignant pleural effusion were 94％ and 74％,98％ and 98％,respectively. Conclusions ENO1 combined with serum CYFRA21-1 and CA125 detection can improve the sensitivity of diagnosis of malignant pleural effusion and enhance the diagnostic rate of malignant pleural effusion.
