Relationship between optimal cutoff value of serum homocysteine and risk factors of premature delivery and its logistic regression analysis
10.3969/j.issn.1006-5725.2017.19.025
- VernacularTitle:血清Hcy水平最佳切点与早产危险因素关系及其Logistic回归分析
- Author:
Weimin HAO
1
;
Honglin XIA
;
Kailei ZHAO
;
Yan HUANG
;
Jie LIU
;
Xiaochun YANG
Author Information
1. 234000,安徽医科大学附属宿州市立医院检验科
- Keywords:
Hcy;
premature delivery;
risk factors;
Logistic regression;
optimal cut off point
- From:
The Journal of Practical Medicine
2017;33(19):3250-3254
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between the optimal cutoff point of serum homocyste-ine(Hcy)and premature delivery in pregnant women ,and to analyze the influence of Hcy levels on the outcome of preterm infants. Methods Totally 114 cases of pregnant women were chosen as observation group and 103 cases of normal as control group. Hcy,D-D and hypersensitive C reactive protein were detected;analysis of the ROC curve was conducted by using the SPSS 13 software and the risk factors for preterm delivery were analyzed using logistic multivariate regression analysis. Results (1)The levels of Hcy,HS-CRP and D-D in preterm pregnant women were higher than those in control group and the difference was statistically significant (P < 0.05). (2) Logistic regression analysis showed that the relative risk coefficient(OR)of Hcy was 9.736,and the regression equation of premature birth probability was obtained.(3)ROC curve to evaluate the predictive value of Hcy in risk factors of preterm birth was 0.931;when Hcy was 13.8μmol/L,the Youden index was 0.784.(4)Elevated levels of Hcy in preterm women led to a marked increase in the likelihood of SGA. Conclusion When predicting risk factors for preterm birth,the best predictive cutoff value for Hcy is 13.8μmol/L,which is one of the independent risk factors for preterm birth.
