The role of inflammatory cytokines in patients with depression in Parkinson's disease
10.3969/j.issn.1006-5725.2017.19.026
- VernacularTitle:帕金森病合并抑郁与血清细胞因子的相关研究
- Author:
Yingjun OUYANG
1
;
Aiwu WU
;
Jianmin YU
;
Huili ZHANG
;
Hui DAI
Author Information
1. 广州医科大学附属广州市第一人民医院神经内科
- Keywords:
depression in Parkinson′s disease;
Parkinson′s disease;
depression disorder;
IL-6;
IL-18;
TNF-α
- From:
The Journal of Practical Medicine
2017;33(19):3255-3260
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the serum levels of interleukin(IL)-6,IL-18 and tumor necrosis factor alpha(TNF-α)in patients with DPD,PD,depression disorder and healthy controls and to analyze the correlations of serum inflammatory factors in DPD patients. Methods Serum levels of IL-6,IL-18 and TNF-αwere measured using enzyme linked immunosorbent assay(ELISA) kits. Several scales were performedin DPD patients. Results DPD,PD and depression disorder patients had significant lower baseline levels of IL-6 and TNF-αwhen compared to healthy controls(P < 0.05). The levels of IL-6 and TNF-α in DPD patients were significantly increased after 4 weeks of anti-depression treatment(P < 0.05). No difference of cytokines levels in gender and in severity of DPD patients was detected Serum levels of these inflammatory cytokines were not significantly correlated with the UP-DRS Ⅲ,H & Y,MMSE and HAMD scores in DPD patients. Conclusions Serum inflammatory factors(IL-6, TNF-α)were altered in patients with DPD in the earlier course of disease. However ,the role of IL-18 remained unknownin the occurrence of DPD disease.
