Relationship between the genetic factors and lamotrigine efficacy in epileptic children received valproic ac-id therapy in south China
10.3969/j.issn.1006-5725.2017.19.033
- VernacularTitle:遗传因素与合用丙戊酸的南方癫痫患儿对拉莫三嗪疗效的相关性
- Author:
Yanling HE
1
;
Fan HE
;
Xiaolan MO
;
Jiali LI
;
Xueding WANG
;
Jie ZHANG
;
Juan CHEN
;
Yuguan WEN
;
Dewei SHANG
;
Lianbing YECHUN
;
HOU YANG
Author Information
1. 南方医科大学南方医院药学部
- Keywords:
epilepsy;
lamotrigine;
valproic acid;
children
- From:
The Journal of Practical Medicine
2017;33(19):3280-3283
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of age,gender,weight and UGT1A4142T>G gene poly-morphism on the efficacy of LTG in epileptic children treated with valproic acid ,and to determine the effective se-rum concentration of LTG in children with epilepsy in south China. Methods A total of 72 pediatric patients with epilepsy received LTG and VPA treatments were enrolled in this study. Patients were treated from January 2010 to September 2016 in Guangzhou women and childrens′medical center. Serum concentration of LTG was measured by using the liquid chromatography-tandem mass spectrometry. UGT1A4142T > G was genotyped by the polymerase chain reaction-restriction fragment length polymorphism method. The correlations between the efficacy of LTG and age,gender,weight were analyzed by chi-square test,non-parametric test and logistic regression analysis,respec-tively. Results The curative effect of patients who were younger and with lighter weight were relatively poor ,and men were better than women in the curative effect. UGT1A4142T > G was not related with LTG efficacy. When combined with VPA,the effective serum concentration of LTG in children with epilepsy was more than 2 g/mL. Conclusion There is a good correlation between age and LTG curative effect. The effective serum concentration of LTG in children with epilepsy,who were co-treated with VPA,was more than 2 g/mL. This study provides a refer-ence for the individual administration of children with epilepsy in south China.
