Study on relations between cystatin C and its polymorphism and metabolic syndrome in Zhuang population of Guangxi district
10.3969/j.issn.1673-4130.2017.18.005
- VernacularTitle:胱抑素C及其基因多态性与广西壮族人群代谢综合征的研究
- Author:
Lan YANG
1
;
Junjia LU
;
Qiulian WU
;
Kaimin YU
;
Liping ZHENG
Author Information
1. 广西医科大学第三附属医院暨南宁市第二人民医院
- Keywords:
cystatin C;
polymorphism;
Zhuang nationality;
metabolic syndrome
- From:
International Journal of Laboratory Medicine
2017;38(18):2509-2512,2516
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation of cystatin C(Cys C) serum level and its gene polymorphism among Zhuang population with Metabolic Syndrome(MS) of Guangxi district.Methods The levels of serum Cys C in Zhuang MS patients,Han MS patients,Zhuang normal people and Han normal people(each of 100 cases)were detected by Immunoturbidimetric Assays.Cys C +148,Cys C+73 and Cys C-82 genotyping were conducted by using PCR-RFLP.Results The clinical data and serum Cys C levels of four groups were significantly different(P＜0.05),The clinical data and serum Cys C levels of two CHD groups were significantly different from those in the two normal groups(P＜0.05);(2) There was a positive correlation between Cys C levels and creatinine(Cr) level in peripheral blood(r=0.551,P=0.000);(3) There was no significant difference in the genotype frequencies of Cys C+73,Cys C+ 148 and Cys C-82 in 4 groups(x2 =3.139,0.791;x2 =4.841,P=0.564;x2 =3.207,P=0.782);(4)Cys C level in MS patients of Cys C+73 GG genotype was significantly lower than that of AG and AA genotype,and the difference was statistically significant (P ＜ 0.05).But there was no significant difference in Cys C level between AG type and AA type.Conclusion The high level of Cys C caused by impaired renal function may be a risk factor for MS patients in Zhuang and Han population in Guangxi.Cys C+73 locus gene polymorphism and the relationship between MS patients in Guangxi Zhuang population need further study.
